منابع مشابه
Human Transposon Tectonics
Mobile DNAs have had a central role in shaping our genome. More than half of our DNA is comprised of interspersed repeats resulting from replicative copy and paste events of retrotransposons. Although most are fixed, incapable of templating new copies, there are important exceptions to retrotransposon quiescence. De novo insertions cause genetic diseases and cancers, though reliably detecting t...
متن کاملCharon tectonics
New Horizons images of Pluto's companion Charon show a variety of terrains that display extensional tectonic features, with relief surprising for this relatively small world. These features suggest a global extensional areal strain of order 1% early in Charon's history. Such extension is consistent with the presence of an ancient global ocean, now frozen.
متن کاملSite-directed transposon integration in human cells
The Sleeping Beauty (SB) transposon is a promising gene transfer vector that integrates nonspecifically into host cell genomes. Herein, we attempt to direct transposon integration into predetermined DNA sites by coupling a site-specific DNA-binding domain (DBD) to the SB transposase. We engineered fusion proteins comprised of a hyperactive SB transposase (HSB5) joined via a variable-length link...
متن کاملPlanetary tectonics: introduction
The geocentric realm of tectonics changed with the dawn of robotic exploration of the other bodies of the solar system. A diverse assortment of tectonic landforms has been revealed, some familiar and some with no analogues to terrestrial structural features. In this chapter, we briefly introduce some of the major topics in the book. The chapters review what is known about the tectonics on Mercu...
متن کاملIntroduction to Tectonics
The Earth is composed of layers of different composition and physical properties, principally the solid central core, the fluid peripheral core, the viscous mantle, and the solid lithosphere. The lithosphere is comprised of the upper mantle and the crust, the outer shell of the Earth. There are two types of lithosphere, according to the crust resting on the solid mantle lithosphere (lithospheri...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Cell
سال: 2012
ISSN: 0092-8674
DOI: 10.1016/j.cell.2012.04.019